Dementia with Lewy bodies (DLB): differential diagnosis

Evidence-based neurology checklist on dementia with lewy bodies (dlb): differential diagnosis: Alzheimer’s disease (AD) About 50% of people with DLB only have cognitive symptoms in life Up to 50% of AD cases have a mixed AD/DLB neuropathology Prodromal DLB is more likely than AD to have the…

Alzheimer’s disease (AD)

  • About 50% of people with DLB only have cognitive symptoms in life
  • Up to 50% of AD cases have a mixed AD/DLB neuropathology
  • Prodromal DLB is more likely than AD to have the following features:

Parkinson’s disease dementia (PDD)

SNCA genetic mutations

Other differentials

References

  1. Outeiro TF, Koss DJ, Erskine D, et al. Dementia with Lewy bodies: an update and outlook. Mol Neurodegener 2019; 14:5.
  2. Wyman-Chick KA, Ferman TJ, Weintraub D, et al. Distinguishing prodromal dementia with Lewy bodies from prodromal Alzheimer disease: a longitudinal study. Neurol Clin Pract 2025; 15:e200380.
  3. Abe K, Chiba Y. A case of treatable dementia with Lewy bodies remarkably improved by immunotherapy. J Neuroimmunol 2019; 330:35-37.
  4. Ikawa F, Sumi N, Nishikawa T, Maruyama H, Miyachi T. A case of dementia with Lewy bodies and Hashimoto encephalopathy successfully treated with immunotherapy. Rinsho Shinkeigaku 2019; 59:102-104.
  5. Nagahama Y, Fukui T. Dementia with Lewy bodies presenting as frontotemporal dementia phenotype. Psychogeriatrics 2019; 19:505-509.
  6. And 2 more. Subscribe to see the full list

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