Cytotoxic lesions of the corpus callosum (CLOCC): clinical and radiological features

Evidence-based neurology checklist on cytotoxic lesions of the corpus callosum (clocc): clinical and radiological features: Possible pathogenetic mechanisms Cytokine cascade activation Blood–brain barrier leakage Glutamate toxicity Clinical features Magnetic resonance imaging (MRI) features Synonyms

Possible pathogenetic mechanisms

  • Cytokine cascade activation
  • Blood–brain barrier leakage
  • Glutamate toxicity

Clinical features

Magnetic resonance imaging (MRI) features

Synonyms

References

  1. Scoppettuolo P, Sinkunaite L, Topciu MF, Schulz J. Cytotoxic lesions of the corpus callosum during the course of ketotic hyperglycemia revealing type I diabetes: a case report. SAGE Open Med Case Rep 2023; 11:2050313X231172338.
  2. Elkhaled W, Ben Abid F, Akhtar N, Abukamar MR, Ibrahim WH. A 23-year-old man with SARS-CoV-2 infection who presented with auditory hallucinations and imaging findings of cytotoxic lesions of the corpus callosum (CLOCC). Am J Case Rep 2020; 21:e928798.
  3. Doherty MJ, Jayadev S, Watson NF, et al. Clinical implications of splenium magnetic resonance imaging signal changes. Arch Neurol 2005; 62: 433–437.
  4. Sousa A, Silva TM, Conceição C, Vieira JP, Gouveia C, Varandas L. Cerebral malaria and cytotoxic lesions of the corpus callosum. Pediatr Infect Dis J 2023; 42:e358-e359.
  5. Garcia-Monco JC, Cortina IE, Ferreira E, et al. Reversible splenial lesion syndrome (RESLES): what's in a name? J Neuroimaging 2011; 21:e1-e14.
  6. And 3 more. Subscribe to see the full list

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