Clinically isolated syndrome (CIS): clinical features
Evidence-based neurology checklist on clinically isolated syndrome (cis): clinical features: Atypical symptoms of CIS Cognitive symptoms Seizures Encephalopathy Cauda equina syndrome Painless optic neuritis Bilateral optic neuritis Vitritis Neuroretinitis Movement disorders Areflexia Paroxysmal…
Atypical symptoms of CIS
- Cognitive symptoms
- Seizures
- Encephalopathy
- Cauda equina syndrome
- Painless optic neuritis
- Bilateral optic neuritis
- Vitritis
- Neuroretinitis
- Movement disorders
- Areflexia
- Paroxysmal symptoms lasting >24 hours
Acute treatment
Disease modifying treatments (DMTs): use in CIS
Disease modifying treatments (DMTs): agents
References
- Miller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol 2012; 11:157-169.
- Marcus JF, Waubant EL. Updates on clinically isolated syndrome and diagnostic criteria for multiple sclerosis. Neurohospitalist 2013; 3:65-80.
- Cobo-Calvo A, Tur C, Otero-Romero S, et al. Association of very early treatment initiation with the risk of long-term disability in patients with a first demyelinating event. Neurology 2023 (Online ahead of print).
- Wiendl H, Gold R, Berger T, et al. Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper). Ther Adv Neurol Disord 2021; 14:17562864211039648.
- García Merino A, Ramón Ara Callizo J, Fernández Fernández O, et al. Consensus statement on the treatment of multiple sclerosis by the Spanish Society of Neurology in 2016. Neurologia 2017; 32:113-119.
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