Alzheimer’s disease (AD) with normal pressure hydrocephalus (NPH)
Evidence-based neurology checklist on alzheimer’s disease (ad) with normal pressure hydrocephalus (nph): Pathological relationship AD pathology is frequent in patients with NPH About 20% of shunt-treated NPH patients have AD pathology on their brain biopsy About 90% of autopsy cases of NPH have AD…
Pathological relationship
- AD pathology is frequent in patients with NPH
- About 20% of shunt-treated NPH patients have AD pathology on their brain biopsy
- About 90% of autopsy cases of NPH have AD pathology
Imaging relationship
Cerebrospinal fluid (CSF) relationship
References
- Müller-Schmitz K, Krasavina-Loka N, Yardimci T, et al. Normal pressure hydrocephalus associated with Alzheimer's Disease. Ann Neurol 2020 (Online ahead of print).
- Pomeraniec IJ, Bond AE, Lopes MB, Jane JA Sr. Concurrent Alzheimer's pathology in patients with clinical normal pressure hydrocephalus: correlation of high-volume lumbar puncture results, cortical brain biopsies, and outcomes. J Neurosurg 2016; 124:382-388.
- Savolainen S, Paljärvi L, Vapalahti M. Prevalence of Alzheimer's disease in patients investigated for presumed normal pressure hydrocephalus: a clinical and neuropathological study. Acta Neurochir (Wien) 1999; 141:849-853.
- Golomb J, Wisoff J, Miller DC, et al. Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response. JNNP 2000; 68:778-781.
- Cabral D, Beach TG, Vedders L, Sue LI, Jacobson S, Myers K, Sabbagh MN. Frequency of Alzheimer's disease pathology at autopsy in patients with clinical normal pressure hydrocephalus. Alzheimers Dement 2011; 7:509-513.
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