White matter lesions (WML): disease patterns
Evidence-based neurology checklist on white matter lesions (wml): disease patterns: Adrenoleukodystrophy (ALD) White matter lesions here are initially occipital They affect the splenium of the corpus callosum and the posterior limb of the internal capsule There is peripheral contrast enhancement…
Adrenoleukodystrophy (ALD)
- White matter lesions here are initially occipital
- They affect the splenium of the corpus callosum and the posterior limb of the internal capsule
- There is peripheral contrast enhancement
- Spinal cord atrophy may be present
Adult onset Alexander disease
CADASIL
Cerebrotendinous xanthomatosis (CTX)
Krabbe disease
Metachromatic leukodystrophy (MLD)
Mitochondrial disorders
Vanishing white matter disease (VWM)
Acronym
References
- Ahmed RM, Murphy E, Davagnanam I, et al. A practical approach to diagnosing adult onset leukodystrophies. JNNP 2014; 85:770-781.
- Bhidayasiri R, Waters MF, Giza CC. Neurological Differential Diagnosis. A Prioritized Approach. Blackwell Publishing Massachusetts 2005 p 423-425.
- Leite CC, Lucato LT, Santos GT, Kok F, Brandão AR, Castillo M. Imaging of adult leukodystrophies. Arq Neuropsiquiatr 2014; 72:625-632.
