Valproate: clinical use
Evidence-based neurology checklist on valproate: clinical use: Mode of action Valproate possibly enhances sodium channel inactivation Indications Dosing Drugs whose blood levels are increased by Valproate Drugs which increase Valproate blood levels Considerations for using Valproate in women of…
Mode of action
- Valproate possibly enhances sodium channel inactivation
Indications
Dosing
Drugs whose blood levels are increased by Valproate
Drugs which increase Valproate blood levels
Considerations for using Valproate in women of child-bearing potential
Treatment of Valproate overdose
References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia 1995; 36(Suppl 2):S2-S12.
- Johannessen SI, Landmark CJ. Antiepileptic drug interactions-principles and clinical implications. Curr Neuropharmacol 2010; 8:254-267.
- Wieck A, Jones S. Dangers of valproate in pregnancy. BMJ 2018; 361:k1609.
- Chopra A, Kolla BP, Mansukhani MP, Netzel P, Frye MA. Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management. Gen Hosp Psychiatry 2012; 34:290-298.
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