Tuberous sclerosis complex (TSC): treatment

Evidence-based neurology checklist on tuberous sclerosis complex (tsc): treatment: General care Multidisciplinary care Counsel against smoking: tobacco and vaping Counsel against oestrogen use Genetic counselling Advice on sun protection Advice on symptoms of pneumothorax Encourage age-appropriate…

General care

  • Multidisciplinary care
  • Counsel against smoking: tobacco and vaping
  • Counsel against oestrogen use
  • Genetic counselling
  • Advice on sun protection
  • Advice on symptoms of pneumothorax
  • Encourage age-appropriate and influenza vaccinations
  • Advice on recombinant varicella zoster vaccine for those on mTOR inhibitors
  • Advice on avoiding live vaccines for those on mTOR inhibitors

Treatment of seizures

Treatment of TSC lesions

Indications for treating LAM with Sirolimus

Acronym

References

  1. Northrup H, Aronow ME, Bebin EM, et al. Updated International Tuberous Sclerosis Complex diagnostic criteria and surveillance and management recommendations. Pediatr Neurol 2021; 123:50-66.
  2. Northrup H, Krueger DA; International Tuberous Sclerosis Complex Consensus Group. Tuberous Sclerosis Complex Diagnostic Criteria Update: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol 2013; 49:243-254. 
  3. Franz DN, Lawson JA, Yapici Z, et al. Everolimus dosing recommendations for tuberous sclerosis complex-associated refractory seizures. Epilepsia 2018; 59:1188-1197.
  4. Mizuguchi M, Ikeda H, Kagitani-Shimono K, et al. Everolimus for epilepsy and autism spectrum disorder in tuberous sclerosis complex: EXIST-3 substudy in Japan. Brain Dev 2018; pii: S0387-7604(18)30176-1 (Epub ahead of print).
  5. French JA, Lawson JA, Yapici Z, et al. Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study. Lancet 2016; 388:2153-2163.
  6. And 8 more. Subscribe to see the full list

Related checklists

Loading...