Tuberous sclerosis complex (TSC): neurological features

Evidence-based neurology checklist on tuberous sclerosis complex (tsc): neurological features: Seizure features Seizures occur in >60% of cases They are early and severe They are usually focal seizures or infantile spasms Infantile spasms are more frequently seen with TSC1 Diffusion tensor imaging…

Seizure features

  • Seizures occur in >60% of cases
  • They are early and severe
  • They are usually focal seizures or infantile spasms
  • Infantile spasms are more frequently seen with TSC1
  • Diffusion tensor imaging (DTI) may identify epileptogenic tubers

TSC-associated neuropsychiatric disorder (TAND)

Cognitive impairment: predictors

Other neurological features

Reported co-morbidities

References

  1. Leventer RJ, Guerrini R, Dobyns WB. Malformations of cortical development and epilepsy. Dialogues Clin Neurosci 2008; 10:47-62.
  2. Curatolo P, Verdecchia M, Bombardieri R. Tuberous sclerosis complex: a review of neurological aspects. Eur J Paed Neurol 2002; 6:15-23.
  3. Roach ES, Gomez MR, Northup H. Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol 1998; 13:624-628.
  4. Curatolo P, Moavero R, de Vries PJ. Neurological and neuropsychiatric aspects of tuberous sclerosis complex. Lancet Neurol 2015; 14:733-745.
  5. Yogi A, Hirata Y, Karavaeva E, et al. DTI of tuber and perituberal tissue can predict epileptogenicity in tuberous sclerosis complex. Neurology 2015; 85:2011-2015. 
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