Tropical spastic paraparesis (TSP): management
Evidence-based neurology checklist on tropical spastic paraparesis (tsp): management: Blood tests HTLV-1 proviral load HTLV-I Tax mRNA load HTLV-1 antibodies Flower cells: atypical cells with hyperconvoluted nuclei Cerebrospinal fluid (CSF) analysis Magnetic resonance imaging (MRI) Steroid…
Blood tests
- HTLV-1 proviral load
- HTLV-I Tax mRNA load
- HTLV-1 antibodies
- Flower cells: atypical cells with hyperconvoluted nuclei
Cerebrospinal fluid (CSF) analysis
Magnetic resonance imaging (MRI)
Steroid treatment
Non-evidenced treatments
Synonym
References
- Zaninovic V. On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. Int J Infect Dis 1999; 3:168-176.
- Oh U, Jacobson S. Treatment of HTLV-I-associated myelopathy / tropical spastic paraparesis: towards rational targeted therapy. Neurol Clin 2008; 26:781-797.
- Gessain A, Saal F, Gout O, et al. High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. Blood 1990; 75:428-433.
- Morrison AA, Samudralwar RD, Berger JR. Rapidly progressive and relapsing myelitis with human T lymphotropic virus type 1: a case report and review of the literature. Neurol Neuroimmunol Neuroinflamm 2026; 13:e200570.
- Araujo A, Bangham CRM, Casseb J, et al. Management of HAM/TSP: systematic review and consensus-based recommendations 2019. Neurol Clin Pract 2021 (Online ahead of print).
