Tropical spastic paraparesis (TSP): differential diagnosis

Evidence-based neurology checklist on tropical spastic paraparesis (tsp): differential diagnosis: Lathyrism This is caused by excessive ingestion of chickpeas: Lathyrus sativa and Vicius sativa The onset is rapid It presents with pain in the lower limbs and lumbar region Spastic paraparesis…

Lathyrism

  • This is caused by excessive ingestion of chickpeas: Lathyrus sativa and Vicius sativa
  • The onset is rapid
  • It presents with pain in the lower limbs and lumbar region
  • Spastic paraparesis eventually develops
  • It results in lumbar pyramidal tract atrophy

Konzo (Buka Buka)

Hepatitis B virus-associated myelopathy (HBVAM)

Primary progressive multiple sclerosis (PPMS)

Other differentials

Synonym

References

  1. Zaninovic V. On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy. Int J Infect Dis 1999; 3:168-176.
  2. Oh U, Jacobson S. Treatment of HTLV-I-associated myelopathy / tropical spastic paraparesis: towards rational targeted therapy. Neurol Clin 2008; 26:781-797.
  3. Kashala-Abotnes E, Okitundu D, Mumba D, Boivin MJ, Tylleskär T, Tshala-Katumbay D. Konzo: a distinct neurological disease associated with food (cassava) cyanogenic poisoning. Brain Res Bull 2019; 145: 87-91.
  4. Ayabe M, Imaizumi T, Kikuchi M, Hino H, Shoji H. Clinical and immunological findings of hepatitis B virus-associated spastic paraparesis: a comparison with HAM. Rinsho Shinkeigaku 1997; 37:283-286.
  5. Hino H, Ayabe M, Honda J, Shoji H, Oizumi K. Hepatitis B virus antibody positive spastic paraparesis. Rinsho Shinkeigaku 1994; 34:691-695. 
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