Subacute combined degeneration (SCD)

Evidence-based neurology checklist on subacute combined degeneration (scd): Causes Pernicious anaemia Cobalamin C disease Nitrous oxide inhalation and anaesthesia Tripterygium glycoside: treatment for glomerulonephritis Vegan diet Crohn’s disease Common variable immunodeficiency syndrome (CVID)…

Causes

  • Pernicious anaemia
  • Cobalamin C disease
  • Nitrous oxide inhalation and anaesthesia
  • Tripterygium glycoside: treatment for glomerulonephritis
  • Vegan diet
  • Crohn’s disease
  • Common variable immunodeficiency syndrome (CVID)
  • Gastric cancer
  • Gastric resection

Clinical features

Associated features of B12 deficiency

Magnetic resonance imaging (MRI)

Differential diagnosis

Treatment

References

  1. Hemmer B, Glocker FX, Schumacher M, Deuschl G, Lucking CH. Subacute combined degeneration: clinical, electrophysiological, and magnetic resonance findings. JNNP 1998; 65:822-827.
  2. Thomas PK. Subacute combined degeneration. JNNP 1998; 65:807.
  3. Smith SE, Kinney HC, Swoboda KJ, Levy HL. Subacute combined degeneration of the spinal cord in cblC disorder despite treatment with B12. Mol Genet Metab 2006; 88:138-145. 
  4. Keddie S, Adams A, Kelso ARC, et al. No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation. J Neurol 2018; 265:1089-1095.
  5. Renard D, Dutray A, Remy A, Castelnovo G, Labauge P. Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia. Neurol Sci 2009; 30:75-76. 
  6. And 12 more. Subscribe to see the full list

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