Stiff person syndrome (SPS): clinical features

Evidence-based neurology checklist on stiff person syndrome (sps): clinical features: Epidemiology The onset is typically in the 4th to 6th decade Females predominate 2:1 Symptoms improve in pregnancy Features of rigidity Features of spasms Other features Associated autoimmune disorders Associated…

Epidemiology

  • The onset is typically in the 4th to 6th decade
  • Females predominate 2:1
  • Symptoms improve in pregnancy

Features of rigidity

Features of spasms

Other features

Associated autoimmune disorders

Associated cancers

Differential diagnoses

Red flags against SPS diagnosis

SPS in pregnancy

Outcome

References

  1. Lockman J, Burns TM. Stiff person syndrome. Pract Neurol 2007; 7:106-108.
  2. Hadavi S, Noyce AJ, Leslie RD, Giovannoni G. Stiff person syndrome. Pract Neurol 2011; 11:272-282.
  3. Esch ME, Newsome SD. Improvement of stiff-person syndrome symptoms in pregnancy: case series and literature review. Neurol Neuroimmunol Neuroinflamm 2020; pii: e684. 
  4. Dalakas MC. Stiff person syndrome: advances in pathogenesis and therapeutic interventions. Curr Treat Options Neurol 2009; 11:102-110.
  5. Benavides DR, Newsome SD. Serotonin-norepinephrine reuptake inhibitors may exacerbate stiff-person syndrome. Neurol Neuroimmunol Neuroinflamm 2016; 3:e281.
  6. And 8 more. Subscribe to see the full list

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