Statin myopathy: risk factors
Evidence-based neurology checklist on statin myopathy: risk factors: High risk statins: lipophilic statins Cerivastatin: this has the highest risk Simvastatin Atorvastatin Lovastatin Low risk statins: hydrophilic statins Subject-related risk factors Possible genetic risk factors Co-morbid disease…
High risk statins: lipophilic statins
- Cerivastatin: this has the highest risk
- Simvastatin
- Atorvastatin
- Lovastatin
Low risk statins: hydrophilic statins
Subject-related risk factors
Possible genetic risk factors
Co-morbid disease risk factors
Drug-related risk factors
Autoimmune risk factors
Dietary risk factors
References
- Sathasivam S, Lecky B. Statin induced myopathy. BMJ 2008; 337:a2286.
- Sewright KA, Clarkson PM, Thompson PD. Statin myopathy: incidence, risk factors, pathophysiology. Curr Atheroscler Rep 2007; 9:389-396.
- Fernandez G, Spatz ES, Jablecki C, Phillips PS. Statin myopathy: a common dilemma not reflected in clinical trials. Cleve Clinic J Med 2011; 78:393-503.
- Tsushima Y, Hatipoglu B. Statin intolerance: a review and update. Endocr Pract 2023; 29:566-571.
- Graham DJ, Staffs JA, Shatin D, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid lowering drugs. JAMA 2004; 292:2585-2590.
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