Statin induced peripheral neuropathy (PN)

Risk of neuropathy with Statins

• The strength of the risk of neuropathy with Statins is inconclusive
• Most studies and reviews reported no risk or only a weak, minimal, or modest risk
• One major case-control study reported a significant risk

Statin axonal neuropathy

Other statin neuropathy types

Differential diagnosis

References

1. Warendorf JK, Vrancken AFJE, van Eijk RPA, Visser NA, van den Berg LH, Notermans NC. Statins do not increase risk of polyneuropathy: a case-control study and literature review. Neurology 2019; 92:e2136-e2144.
2. Phan T, McLeod JG, Pollard JD, Peiris O, Rohan A, Halpern J-P. Peripheral neuropathy associated with simvastatin. JNNP 1995; 58:635-628.
3. Jeppesen U, Gaist D, Smith T, Sindrup SH. Statins and peripheral neuropathy. Eur J Clin Pharmacol 1999; 54:835-838.
4. Tierney EF, Thurman DJ, Beckles GL, Cadwell BL. Association of statin use with peripheral neuropathy in the U.S. population 40 years of age or older. J Diabetes 2013; 5:207-215. 
5. Corrao G, Zambon A, Bertu L, Botteri E, Leoni O, Contiero P. Lipid lowering drugs prescription and the risk of peripheral neuropathy: an exploratory case-control study using automated databases. J Epidemiol Community Health 2000; 58:1047-1051.
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Related checklists

• Drug-induced peripheral neuropathy (PN): causes
• Colchicine myoneuropathy