Colchicine myoneuropathy
Evidence-based neurology checklist on colchicine myoneuropathy: Neuropathy features The onset is days to weeks after Colchicine treatment or change in renal function It presents with proximal weakness and pain There may be associated myotonia Gastrointestinal symptoms are not always present Other…
Neuropathy features
- The onset is days to weeks after Colchicine treatment or change in renal function
- It presents with proximal weakness and pain
- There may be associated myotonia
- Gastrointestinal symptoms are not always present
Other manifestations of Colchicine toxicity
Risk factors
Differential diagnosis
Raised enzyme levels
Electromyogram (EMG): features
Muscle biopsy
Treatment
References
- Rana SS, Giuliani MJ, Oddis CV, Lacomis D. Acute onset of colchicine myoneuropathy in cardiac transplant recipients: case studies of three patients. Clin Neurol Neurosurg 1997; 99:266-270.
- Kuncl RW, Duncan G, Watson D, Alderson K, Rogawski MA, Peper M. Colchicine myopathy and neuropathy. N Engl J Med 1987; 316:1562-1568.
- Wilbur K, Makowsky M. Colchicine myotoxicity: case reports and literature review. Pharmacotherapy 2004; 24:1784-192.
- Rutkove SB, De Girolami U, Preston DC, et al. Myotonia in colchicine myoneuropathy. Muscle Nerve 1996; 19:870-875.
- Duarte J, Cabezas C, Rodríguez F, Clavería LE, Palacin T. Colchicine-induced myopathy with myotonia. Muscle Nerve 1998; 21:550-551.
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