Small fiber neuropathy: causes

Genetic

• Sodium channel gene mutations: Nav 1.7 channelopathy
• Fabry disease
• Tangier disease
• Familial amyloid polyneuropathy (FAP)
• COL6 gene mutation disorders
• Pompe disease
• Hereditary sensory and motor neuropathy (HSMN)

Immune and inflammatory

Endocrine and metabolic

Infections: major types

Infections: other types

Toxic: main ones

Toxic: others

Vaccinations

Other causes

Causes of loss of small fibers

References

1. Devigili G, Tugnoli V, Penza P, et al. The diagnostic criteria for small fiber neuropathy: from symptoms to neuropathology. Brain 2008; 131:1912-1925.
2. Tavee J, Zhou L. Small fiber neuropathy: a burning problem. Cleve Clin J Med 2009; 76:297-305.
3. Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16:934-944.
4. Hoeijmakers JG, Han C, Merkies IS, et al. Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation. Brain 2012; 135:345-358.
5. Han C, Hoeijmakers JG, Ahn HS, et al. Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability. Neurology 2012; 78:1635-1643. 
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