Sleeping sickness: central features

Evidence-based neurology checklist on sleeping sickness: central features: Stage 1 sleeping sickness This is the early hemolymphatic stage Trypomastigota multiply in blood and lymph nodes The parasites are also in the spleen, liver, skin, heart, eyes, and endocrine system Stage 2 sleeping sickness…

Stage 1 sleeping sickness

  • This is the early hemolymphatic stage
  • Trypomastigota multiply in blood and lymph nodes
  • The parasites are also in the spleen, liver, skin, heart, eyes, and endocrine system

Stage 2 sleeping sickness

Sleep disorders

Psychiatric features

Neuromuscular features

Movement disorders

Primitive reflexes

Other central features

Differential diagnosis

Synonyms

References

  1. Dzikowiec M, Góralska K, Błaszkowska J. Neuroinvasions caused by parasites. Ann Parasitol 2017; 63:243–253.
  2. Malvy D, Chappuis F. Sleeping sickness. Clin Microbiol Infect 2011; 17:986-995. 
  3. Ehrhardt S, Lippert U, Burchard GD, Sudeck H. Orchitis as an unusual manifestation of human African trypanosomiasis. J Infect 2006; 52:e31-e33. 
  4. Stich A, Abel PM, Krishna S. Human African trypanosomiasis. BMJ 2002; 325:203-206. 
  5. Kennedy PG. Human African trypanosomiasis of the CNS: current issues and challenges. J Clin Invest 2004; 113:496-504. 

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