Senile dementia of the neurofibrillary tangle type (SDNFT)

Evidence-based neurology checklist on senile dementia of the neurofibrillary tangle type (sdnft): Epidemiological features The mean onset age mean is 84 years The mean age at death is 91 years The mean dementia duration is 7 years Clinical features Pathological features SD-NFT v Alzheimer’s…

Epidemiological features

  • The mean onset age mean is 84 years
  • The mean age at death is 91 years
  • The mean dementia duration is 7 years

Clinical features

Pathological features

SD-NFT v Alzheimer’s disease (AD) - AD has more severe of the following

Diagnostic criteria

Synonym

References

  1. Tahara N, Tahara D, Akagi A, et al. Hippocampal sclerosis in senile dementia of the neurofibrillary tangle type. J Neurol Sci 2025; 471:123437.
  2. Matsubara T, Ishii K, Saito Y, et al. Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy. Acta Neuropathol Commun 2024; 12:98.
  3. Yamada M, Itoh Y, Sodeyama N, et al. Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer's disease. Dement Geriatr Cogn Disord 2001; 12:117-126.
  4. Yamada M, Itoh Y, Suematsu N, Matsushita M. Dementia of the Alzheimer type and related dementias in the aged: DAT subgroups and senile dementia of the neurofibrillary tangle type. Neuropathology 1996.
  5. Jellinger KA, Attems J. Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease. Acta Neuropathol 2007; 113:107-117.
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