Schizophrenia: pathology and risk factors

Evidence-based neurology checklist on schizophrenia: pathology and risk factors: Pathophysiological hypotheses Dopaminergic Glutamergic Serotoninergic GABAergic Others: histaminergic, muscarinergic, and adrenergic Genetic risk factors: potential susceptibility genes Maternal risk factors…

Pathophysiological hypotheses

  • Dopaminergic
  • Glutamergic
  • Serotoninergic
  • GABAergic
  • Others: histaminergic, muscarinergic, and adrenergic 

Genetic risk factors: potential susceptibility genes

Maternal risk factors

Environmental risk factors

References

  1. Picchioni MM, Murray RM. Schizophrenia. BMJ 2007; 335:91-95. 
  2. Stępnicki P, Kondej M, Kaczor AA. Current concepts and treatments of schizophrenia. Molecules 2018; 23:2087.
  3. Martínez AL, Brea J, Rico S, de Los Frailes MT, Loza MI. Cognitive deficit in schizophrenia: from etiology to novel treatments. Int J Mol Sci 2021; 22:9905.
  4. Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet 2016; 388:86-97.
  5. Kiehl TR, Chow EW, Mikulis DJ, George SR, Bassett AS. Neuropathologic features in adults with 22q11.2 deletion syndrome. Cereb Cortex 2009; 19:153-164.
  6. And 1 more. Subscribe to see the full list

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