REM sleep behaviour disorder (RBD): conversion to Parkinsonism

Evidence-based neurology checklist on rem sleep behaviour disorder (rbd): conversion to parkinsonism: RBD and neurological disorders Neurological diseases occur in about 60% of RBD RBD precedes Parkinsonism in about 50% of cases It especially precedes multiple system atrophy (MSA) It is also…

RBD and neurological disorders

  • Neurological diseases occur in about 60% of RBD
  • RBD precedes Parkinsonism in about 50% of cases
  • It especially precedes multiple system atrophy (MSA)
  • It is also associated with antibodies to IgLON5

Predictors of conversion to Parkinsonism

References

References

  1. Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain 2000; 123:331-339.
  2. Plazzi G, Cortelli P, Montagna P, et al. REM sleep behaviour disorder differentiates pure autonomic failure from multiple system atrophy with autonomic failure. JNNP 1998; 64:683-685.
  3. Postuma RB, Iranzo A, Hu M, et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain 2019; 142:744-759. 
  4. Arnaldi D, Mattioli P, Pardini M, et al. Clinical and dopaminergic imaging characteristics of the FARPRESTO cohort of trial-ready idiopathic rapid eye movement sleep behavior patients. Eur J Neurol 2023; 30:3703-3710.
  5. Terzaghi M, Toscano G, Casoni F, et al. Assessment of cognitive profile as a prodromal marker of the evolution of REM sleep behavior disorder. Sleep 2019; pii: zsz103 (Epub ahead of print).
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