Refractory myasthenia gravis (MG): treatment

Evidence-based neurology checklist on refractory myasthenia gravis (mg): treatment: Plasma exchange (PE) This is a conventional treatment for refractory MG It is also used to achieve remission pre-surgery Intravenous immunoglobulins (IVIg) Rituximab Eculizumab Ravalizumab Emerging treatments

Plasma exchange (PE)

  • This is a conventional treatment for refractory MG
  • It is also used to achieve remission pre-surgery

Intravenous immunoglobulins (IVIg)

Rituximab

Eculizumab

Ravalizumab

Emerging treatments

References

  1. Yamada C, Teener JW, Davenport RD, Cooling L. Maintenance plasma exchange treatment for muscle specific kinase antibody positive myasthenia gravis patients. J Clin Apher 2015; 30:314-319. 
  2. Beecher G, Anderson D, Siddiqi ZA. Subcutaneous immunoglobulin in myasthenia gravis exacerbation: A prospective, open-label trial. Neurology 2017; 89:1135-1141.
  3. Di Stefano V, Lupica A, Rispoli MG, Di Muzio A, Brighina F, Rodolico C. Rituximab in AChR subtype of myasthenia gravis: systematic review. JNNP 2020; 91:392-395.
  4. Sanders DB, Wolfe GI, Benatar M, et al. International consensus guidance for management of myasthenia gravis: executive summary. Neurology 2016; 87:419-425.
  5. Maddison P, McConville J, Farrugia ME, et al. The use of rituximab in myasthenia gravis and Lambert-Eaton myasthenic syndrome. JNNP 2011; 82:671-673.
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