Refractory epilepsy: risk factors

Evidence-based neurology checklist on refractory epilepsy: risk factors: Patient factors Young onset age of epilepsy Depression Structural factors Pediatric syndromes Seizure factors Anti-epileptic drug (AED) factors Genetic predispositions Synonyms

Patient factors

  • Young onset age of epilepsy
  • Depression

Structural factors

Pediatric syndromes

Seizure factors

Anti-epileptic drug (AED) factors

Genetic predispositions

Synonyms

References

  1. Beleza P. Refractory epilepsy: a clinically oriented review. Eur Neurol 2009; 62:65-71.
  2. Saavalainen T, Jutila L, Mervaala E, Kälviäinen R, Vanninen R, Immonen A. Temporal anteroinferior encephalocele: an underrocognized etiology of temporal lobe epilepsy? Neurology 2015; 85:1467-1474.
  3. Gesche J, Khanevski M, Solberg C, Beier CP. Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies. Epilepsia 2017; 58:e64-e69. 
  4. Roy PL, Ronquillo LH, Ladino LD, Tellez-Zenteno JF. Risk factors associated with drug resistant focal epilepsy in adults: a case control study. Seizure 2019; 73:46-50.
  5. Chouchi M, Kaabachi W, Klaa H, Tizaoui K, Turki IB, Hila L. Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis. BMC Neurol 2017; 17:32.
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