Progressive supranuclear palsy (PSP): differential diagnosis

Evidence-based neurology checklist on progressive supranuclear palsy (psp): differential diagnosis: Parkinsonian disorders Parkinson’s disease (PD) Dementia with Lewy bodies (DLB) Multiple system atrophy (MSA) Corticobasal degeneration (CBD) Post encephalitic parkinsonism Perry syndrome…

Parkinsonian disorders

  • Parkinson’s disease (PD)
  • Dementia with Lewy bodies (DLB)
  • Multiple system atrophy (MSA)
  • Corticobasal degeneration (CBD)
  • Post encephalitic parkinsonism
  • Perry syndrome
  • Kufor-Rakeb
  • Gaucher’s disease

Mokri syndrome

Other differentials

Features against a diagnosis of PSP

Acronym

References

  1. Litvan I, Agid A, Calne D, et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-PSP International Workshop. Neurology 1996; 47:1-9.
  2. Ling H, Massey LA, Lees AJ, Brown P, Day BL. Hypokinesia without decrement distinguishes progressive supranuclear palsy from Parkinson's disease. Brain 2012; 135:1141-1153.
  3. Höglinger GU, Respondek G, Stamelou M, et al. Clinical diagnosis of progressive supranuclear palsy: The Movement Disorder Society criteria. Mov Disord 2017; 32:853-864.
  4. Stamelou M, Quinn NP, Bhatia KP. "Atypical" atypical parkinsonism: new genetic conditions presenting with features of progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy-a diagnostic guide. Mov Disord 2013; 28:1184-1199.
  5. Tisel SM, Ahlskog JE, Duffy JR, Matsumoto JY, Josephs KA. PSP-like syndrome after aortic surgery in adults (Mokri syndrome). Neurol Clin Pract 2020; 10:245-254.
  6. And 6 more. Subscribe to see the full list

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