Primary progressive multiple sclerosis (PPMS): management

Evidence-based neurology checklist on primary progressive multiple sclerosis (ppms): management: Magnetic resonance imaging (MRI) features Infrequent contrast enhancing lesions Early spinal cord atrophy Prominent cortical demyelinating lesions Slower rate of new lesions than in relapsing remitting…

Magnetic resonance imaging (MRI) features

  • Infrequent contrast enhancing lesions
  • Early spinal cord atrophy
  • Prominent cortical demyelinating lesions
  • Slower rate of new lesions than in relapsing remitting MS (RRMS)

Magnetic resonance imaging (MRI) lesions more frequent in PPMS

Genetics

Cerebrospinal fluid (CSF) analysis

Disease modifying therapy

Investigational treatments

References

  1. Giovannoni G. Primary progressive multiple sclerosis. ACNR 2012; 12:8-11.
  2. Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol 2007; 6:903-912.
  3. Ingle GT, Thompson AJ, Miller DH. Magnetic resonance imaging in primary progressive multiple sclerosis. J Rehabil Res Dev 2002; 39:261-271.
  4. Siger M. Magnetic resonance imaging in primary progressive multiple sclerosis patients : review. Clin Neuroradiol 2022; 32:625-641.
  5. Elliott C, Wolinsky JS, Hauser SL, et al. Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions. Mult Scler 2018; doi: 10.1177/1352458518814117 (Epub ahead of print).
  6. And 8 more. Subscribe to see the full list

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