Post-traumatic hypopituitarism (PTHP)

Evidence-based neurology checklist on post-traumatic hypopituitarism (pthp): Pathology This is a constellation of hypopituitary symptoms that develop after TBI It is present in about a quarter of cases of TBI It may present years after TBI Risk factors Clinical features Potential mechanisms…

Pathology

  • This is a constellation of hypopituitary symptoms that develop after TBI
  • It is present in about a quarter of cases of TBI
  • It may present years after TBI

Risk factors

Clinical features

Potential mechanisms

Management

Prognosis

References

  1. Leeder S. Traumatic brain injury and hypopituitarism. ACNR 2019; 18:6-9.
  2. Sav A, Rotondo F, Syro LV, Serna CA, Kovacs K. Pituitary pathology in traumatic brain injury: a review. Pituitary 2019; 22:201-211. 
  3. Kgosidialwa O, Agha A. Hypopituitarism post traumatic brain injury (TBI): review. Ir J Med Sci 2019; 188:1201-1206.
  4. Kałas M, Miksiewicz M, Kowalke A, Siemiński M. Post-traumatic hypopituitarism: a neglected consequence of traumatic brain injury. Neuroendocrinology 2023; 113:579-588.
  5. Caputo M, Mele C, Prodam F, Marzullo P, Aimaretti G. Clinical picture and the treatment of TBI-induced hypopituitarism. Pituitary 2019; 22:261-269.

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