Peripheral nerve hyperexcitability (PNH): management

Evidence-based neurology checklist on peripheral nerve hyperexcitability (pnh): management: Blood investigations Creatinine kinase (CK): this is raised in half of cases Anti-VGKC antibodies: these are present in 5-35% of cases Electromyogram (EMG): features Paraneoplastic antibodies Treatment of…

Blood investigations

  • Creatinine kinase (CK): this is raised in half of cases
  • Anti-VGKC antibodies: these are present in 5-35% of cases

Electromyogram (EMG): features

Paraneoplastic antibodies

Treatment of neuromyotonia

Immunosuppression

Acronym

References

  1. Hart IK, Maddison P, Newsome-Davis J, Vincent A, Mills KR. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 2002; 125:1887-1895.
  2. Rubio-Agusti I, Perez-Miralles F, Sevilla T, et al. Peripheral nerve hyperexcitability: a clinical and immunological study of 38 patients. Neurology 2011; 76:172-178.
  3. Maddison P. Neuromyotonia. Clin Neurophysiol 2006; 117:2118-2127.
  4. Skeie GO, Apostolski S, Evoli A, et al. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2006; 13:691-699.

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