Parkinson's disease (PD): differential diagnosis

Evidence-based neurology checklist on parkinson's disease (pd): differential diagnosis: Parkinson’s plus syndromes Multiple system trophy (MSA): the following are more impaired in MSA Dementia with Lewy bodies (DLB) Progressive supranuclear palsy (PSP) Corticobasal degeneration (CBD) Other…

Parkinson’s plus syndromes

  • Multiple system trophy (MSA): the following are more impaired in MSA
  • Dementia with Lewy bodies (DLB)
  • Progressive supranuclear palsy (PSP)
  • Corticobasal degeneration (CBD)

Other neurodegenerative disorders

Developmental disorders

Chromosomal disorders

Brain tumours

Brain cysts

Other brain structural disorders

Toxin-induced Parkinsonism

Drug-induced Parkinsonism

Other differentials

Red flags against PD diagnosis

References

  1. Massano J, Bhatia K. Clinical approach to Parkinson's disease: features, diagnosis, and principles of management. Cold Spring Harb Perspect Med 2012; 2:a008870.
  2. Gigante AF, Berardelli A, Defazio G. Rest tremor in idiopathic adult-onset dystonia. Eur J Neurol 2016; 23:935-939.
  3. Shin HW, Hong SW, Youn YC. Clinical aspects of the differential diagnosis of Parkinson's disease and Parkinsonism. J Clin Neurol 2022; 18:259-270.
  4. von Scheibler ENMM, van Eeghen AM, de Koning TJ, et al. Parkinsonism in genetic neurodevelopmental disorders: a systematic review. Mov Disord Clin Pract 2022; 10:17-31.
  5. Sista SR, Dronacharya L. Manganese supplementation as a cause of parkinsonism and T1-hyperintensities on basal ganglia. Neurol Clin Pract 2021; 11:e361-e362.
  6. And 17 more. Subscribe to see the full list

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