Paraneoplastic encephalitis (PE): management

Evidence-based neurology checklist on paraneoplastic encephalitis (pe): management: Investigations: non-invasive Paraneoplastic antibody screening Full-body CT Positron emission tomography (PET) Magnetic resonance imaging (MRI) brain Electroencephalogram (EEG) Investigations: surgical exploration…

Investigations: non-invasive

  • Paraneoplastic antibody screening
  • Full-body CT
  • Positron emission tomography (PET)
  • Magnetic resonance imaging (MRI) brain
  • Electroencephalogram (EEG)

Investigations: surgical exploration

Symptomatic treatments

First line immunotherapy

Second line immunotherapy

Other treatments

References

  1. Vaišvilas M, Ciano-Petersen NL, Macarena Villagrán-García MD, Muñiz-Castrillo S, Vogrig A, Honnorat J. Paraneoplastic encephalitis: clinically based approach on diagnosis and management. Postgrad Med J 2023 (Online ahead of print).
  2. Honnorat J, Antoine JC. Paraneoplastic neurological syndromes. Orphant J Rare Dis 2007; 2:22.
  3. Voltz RD, Posner JB, Dalmau J, Graus F. Paraneoplastic encephalomyelitis: an update of the effects of the anti-Hu immune response on the nervous system and tumour. JNNP 1997; 63:133-136.
  4. Grisold W, Giometto B, Vitaliani R, Oberndorfer S. Current approaches to the treatment of paraneoplastic encephalitis. Ther Adv Neurol Disord 2011; 4:237-248.
  5. Batson OA, Fantle DM, Stewart JA. Paraneoplastic encephalomyelitis. Dramatic response to chemotherapy alone. Cancer 1992; 69:1291-1293.

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