Oxaliplatin induced neuropathy

Evidence-based neurology checklist on oxaliplatin induced neuropathy: Acute neurotoxicity Oxaliplatin causes cold -triggered paraesthesias or dysesthesias These develop immediately after infusion They affect the distal extremities or perioral region There are pharyngolaryngeal dysesthesias in some…

Acute neurotoxicity

  • Oxaliplatin causes cold -triggered paraesthesias or dysesthesias
  • These develop immediately after infusion
  • They affect the distal extremities or perioral region
  • There are pharyngolaryngeal dysesthesias in some cases
  • There may be associated tetanic spasms
  • Fasciculations may be evident
  • There may be muscle contractions of the extremities or the jaw

Cumulative neurotoxicity

Management

Outcome

References

  1. Velasco R, Bruna J, Briani C, Argyriou AA, et al. Early predictors of oxaliplatin-induced cumulative neuropathy in colorectal cancer patients. JNNP 2014; 85:392-398.
  2. Saif MW, Reardon J. Management of oxaliplatin-induced peripheral neuropathy. Ther Clin Risk Manag 2005; 1:249-258.
  3. Briani C, Argyriou AA, Izquierdo C, et al. Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study. J Peripher Nerv Syst 2014; 19:299-306.

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