Opsoclonus myoclonus syndrome (OMS): clinical features

Evidence-based neurology checklist on opsoclonus myoclonus syndrome (oms): clinical features: Opsoclonus This is a chaotic multidirectional eye movement disorder (saccadomania) The movements are conjugate or semi-conjugate They are startle and stimulus sensitive They may occur in bouts They may…

Opsoclonus

  • This is a chaotic multidirectional eye movement disorder (saccadomania)
  • The movements are conjugate or semi-conjugate
  • They are startle and stimulus sensitive
  • They may occur in bouts
  • They may manifest with or without myoclonus
  • The symptoms improve when the eyes are shut
  • They also improve in sleep
  • They are worsened with eye movements and fixation
  • They may persist in coma
  • There may be associated oscillopsia
  • There is no associated diplopia

Myoclonus

Other features

Differential diagnosis of opsoclonus

Synonym

References

  1. Sahu JK, Prasad K. The opsoclonus myoclonus syndrome. Pract Neurol 2011; 11:160-166.
  2. Pranzatelli MR. The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol 1992; 15:186-228.
  3. Bataller L, Graus F, Saiz A, et al. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Brain 2001; 124:437-443.
  4. Brunklaus A, Pohl K, Zuberi SM, de Sousa C. Outcome and prognostic features in opsoclonus-myoclonus syndrome from infancy to adult life. Pediatrics 2011; 128:e388-e394.

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