Opsoclonus myoclonus syndrome (OMS): causes

Evidence-based neurology checklist on opsoclonus myoclonus syndrome (oms): causes: Primary neurological causes Idiopathic (I-OMS): this has a younger onset and better outcomes Anti-glutamate receptor δ2 antibodies (anti GluD2) Anti-dendritic surface receptor antibodies Hydrocephalus Lafora body…

Primary neurological causes

  • Idiopathic (I-OMS): this has a younger onset and better outcomes
  • Anti-glutamate receptor δ2 antibodies (anti GluD2)
  • Anti-dendritic surface receptor antibodies
  • Hydrocephalus
  • Lafora body disease
  • Multiple sclerosis (MS)
  • Friedreich's ataxia (FA)
  • Thalamic haemorrhage
  • Pontine haemorrhage

Paraneoplastic (P-OMS)

Viral causes

Bacterial causes

Other causes

References

  1. Sahu JK, Prasad K. The opsoclonus myoclonus syndrome. Pract Neurol 2011; 11:160-166.
  2. Pranzatelli MR. The neurobiology of the opsoclonus-myoclonus syndrome. Clin Neuropharmacol 1992; 15:186-228.
  3. Armangué T, Sabater L, Torres-Vega E, et al. Clinical and immunological features of opsoclonus-myoclonus syndrome in the era of neuronal cell surface antibodies. JAMA Neurol 2016; 73:417-424. 
  4. Berridge G, Menassa DA, Moloney T, et al. Glutamate receptor δ2 serum antibodies in pediatric opsoclonus myoclonus ataxia syndrome. Neurology 2018; 91:e714-e723. 
  5. Panzer JA, Anand R, Dalmau J, Lynch DR. Antibodies to dendritic neuronal surface antigens in opsoclonus myoclonus ataxia syndrome. J Neuroimmunol 2015; 286:86-92.
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