Neuropsychiatric systemic lupus erythematosus (NPSLE): treatment
Evidence-based neurology checklist on neuropsychiatric systemic lupus erythematosus (npsle): treatment: First line treatment of vasculitic or inflammatory features Intravenous Methylprednisolone 1g daily for 3 days Cyclophosphamide 0.5-1g/square meter monthly for 6 months Convert to maintenance…
First line treatment of vasculitic or inflammatory features
- Intravenous Methylprednisolone 1g daily for 3 days
- Cyclophosphamide 0.5-1g/square meter monthly for 6 months
- Convert to maintenance immunosuppressants if response is complete
Second line treatment options
Treatment of thrombotic features
Symptomatic treatments
Investigational treatments
References
- Popescu A, Kao AH. Neuropsychiatric systemic lupus erythematosus. Curr Neuropharmacol 2011; 9:449-457.
- Magro-Checa C, Zirkzee EJ, Huizinga TW, Steup-Beekman GM. Management of neuropsychiatric systemic lupus erythematosus: current approaches and future perspectives. Drugs 2016; 76:459-483.
- Hussain A, Mir TH, Dar MA, et al. Systemic lupus erythematous presenting as catatonia and its response to electroconvulsive therapy. Indian J Psychol Med 2015; 37:456-459.
