Neuromyelitis optica (NMO): acute treatment

Evidence-based neurology checklist on neuromyelitis optica (nmo): acute treatment: Steroids Methylprednisolone Then followed by oral steroids for 2-6 months Plasma exchange (PE) Treatment of tonic spasms Predictors of poor response to treatment

Steroids

  • Methylprednisolone
  • Then followed by oral steroids for 2-6 months

Plasma exchange (PE)

Treatment of tonic spasms

Predictors of poor response to treatment

References

  1. Argyriou AA, Makris N. Neuromyelitis optica: a distinct demyelinating disease of the central nervous system. Acta Neurol Scand 2008; 128:209-217.
  2. Palace J, Leite I, Jacob A. A practical guide to the treatment of neuromyelitis optica. Pract Neurol 2012; 12:209-214.
  3. Scott TF, Frohman EM, De Seze J, Gronseth GS, Weinshenker BG. Evidence-based guideline: clinical exaltation and treatment of transverse myelitis. Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2011; 77:2128-2134.
  4. Bonnan M, Valentino R, Debeugny S, et al. Short delay to initiate plasma exchange is the strongest predictor of outcome in severe attacks of NMO spectrum disorders. JNNP 2018; 89:346-351.
  5. Jiao Y, Cui L, Zhang W, et al. Plasma exchange for neuromyelitis optica spectrum disorders in chinese patients and factors predictive of short-term outcome. Clin Ther 2018; 40:603-612.
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