Neurofibromatosis type 2 (NF2) tumours

Pathology

• NF2 is a tumour predisposition syndrome
• It is defined by vestibular schwannomas
• There is also an association with other tumours

Revised Manchester diagnostic criteria

Vestibular schwannomas

Non-vestibular schwannomas

Meningiomas

Other tumours

Differential diagnosis

Synonym

References

1. Ferner RE. The neurofibromatoses. Pract Neurol 2010; 10:82-93.
2. Ferner RE. Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol 2007; 6:340-351.
3. Gregory GE, Islim AI, Hannan CJ, et al. The clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis. Neurooncol Adv 2023; 5(Suppl 1):i94-i104.
4. Gareth D, Evans R. Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis 2009; 4:16.
5. Evans DGR, Salvador H, Chang VY, et al. Cancer and central nervous system tumor surveillance in pediatric neurofibromatosis 2 and related disorders. Clin Cancer Res 2017; 23:e54-e61. 
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Related checklists

• Neurofibromatosis type 2 (NF2): clinical features
• Neurofibromatosis type 2 (NF2): screening and surveillance
• Neurofibromatosis type 2 (NF2): management