Multiple system atrophy (MSA): differential diagnosis

Evidence-based neurology checklist on multiple system atrophy (msa): differential diagnosis: Idiopathic late onset cerebellar ataxia (ILOCA) MSA may be distinguished by the phalanx sign This is observed during the finger-nose test of coordination The subject points at or below the distal…

Idiopathic late onset cerebellar ataxia (ILOCA)

  • MSA may be distinguished by the phalanx sign
  • This is observed during the finger-nose test of coordination
  • The subject points at or below the distal interphalangeal joint instead of the fingertip

Parkinsonian disorders

Other neurological disorders

References

  1. Schneider V, Wirth T, Iosif A, et al. "Phalanx sign" helps to discriminate MSA-C from idiopathic late onset cerebellar ataxia. J Neurol 2022; 269:3900-3903.
  2. Stamelou M, Quinn NP, Bhatia KP. "Atypical" atypical parkinsonism: new genetic conditions presenting with features of progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy-a diagnostic guide. Mov Disord 2013; 28:1184-1199.
  3. Goh YY, Saunders E, Pavey S, Rushton E, Quinn N, Houlden H, Chelban V. Multiple system atrophy. Pract Neurol 2023; 23:208-221.
  4. Labate A, Nisticò R, Cherubini A, Quattrone A. Midbrain meningioma causing subacute parkinsonism. Neurol Clin Pract 2018; 8:166-168.

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