Multiple sclerosis (MS): other MRI differentials

Evidence-based neurology checklist on multiple sclerosis (ms): other mri differentials: CADASIL This shows confluent lesions usually in the anterior temporal poles There are also lesions in the thalamus, brainstem, and external capsule Microbleeds are often seen on gradient echo MRI Primary…

CADASIL

  • This shows confluent lesions usually in the anterior temporal poles
  • There are also lesions in the thalamus, brainstem, and external capsule
  • Microbleeds are often seen on gradient echo MRI

Primary angiitis of the central nervous system (PACNS)

Systemic lupus erythematosus (SLE)

Small vessel disease (SVD)

Infective differentials

Brain tumours

Other radiological differentials

Acronym

References

  1. Charil A, Yousry TA, Rovaris M. MRI and the diagnosis of multiple sclerosis: expanding the concept of “no better explanation”. Lancet Neurol 2006; 5:841-852.
  2. Falini A, Kesavadas C, Pontesilli S, Rovaris M, Scotti G. Differential diagnosis of posterior fossa multiple sclerosis lesions-neuroradiological aspects. Neurol Sci 2001; 22:S79-S83.
  3. Bastianello S, Pichiecchio A, Spadaro M, et al. Atypical multiple sclerosis: MRI findings and differentials. Neurol Sci 2004; S356-S360.
  4. Samaraweera APR, Falah Y, Pitiot A, Dineen RA, Morgan PS, Evangelou N. The MRI central vein marker; differentiating PPMS from RRMS and ischemic SVD. Neurol Neuroimmunol Neuroinflamm 2018; 5:e496. 
  5. Lin X, Yu W-Y, Liauw L, et al. Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms. Neurol Clin Pract 2017; 7:53-64.

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