Monomethyl fumarate
Evidence-based neurology checklist on monomethyl fumarate: Mode of action It is the active metabolite of dimethyl fumarate It reduces the level of circulating lymphocytes It also modifies monocyte activation It alters the transcription factor nuclear factor erythroid-derived 2-like 2 (NFE2L2 or…
Mode of action
- It is the active metabolite of dimethyl fumarate
- It reduces the level of circulating lymphocytes
- It also modifies monocyte activation
- It alters the transcription factor nuclear factor erythroid-derived 2-like 2 (NFE2L2 or NRF2)
Indications
Dose
Adverse effects
Monitoring
References
- Derfuss T, Mehling M, Papadopoulou A, Bar-Or A, Cohen JA, Kappos L. Advances in oral immunomodulating therapies in relapsing multiple sclerosis. Lancet Neurol 2020; 19:336-347.
- Berger AA, Sottosanti ER, Winnick A, et al. Monomethyl mumarate (MMF, Bafiertam) for the treatment of relapsing forms of multiple sclerosis (MS). Neurol Int 2021; 13:207-223.
