Cladribine
Evidence-based neurology checklist on cladribine: Pharmacology Cladribine is 2-chlorodeoxyadenosine It is an adenosine deaminase-resistant purine nucleoside It depletes memory B cells Indications Dosing Benefits Adverse effects: dermatological Adverse effects: others Adverse effects: case reports
Pharmacology
- Cladribine is 2-chlorodeoxyadenosine
- It is an adenosine deaminase-resistant purine nucleoside
- It depletes memory B cells
Indications
Dosing
Benefits
Adverse effects: dermatological
Adverse effects: others
Adverse effects: case reports
References
- Wiendl H. Cladribine-an old newcomer for pulsed immune reconstitution in MS. Nat Rev Neurol 2017; 13:573-574.
- Giovannoni G, Soelberg Sorensen P, et al. Safety and efficacy of cladribine tablets in patients with relapsing-remitting multiple sclerosis: results from the randomized extension trial of the CLARITY study. Mult Scler 2017; doi: 10.1177/1352458517727603 (Epub ahead of print).
- Holmøy T, Torkildsen Ø, Myhr KM. An update on cladribine for relapsing-remitting multiple sclerosis. Expert Opin Pharmacother 2017; 18:1627-1635.
- Kim W, Zandoná ME, Kim S-H, Kim HJ. Oral disease-modifying therapies for multiple sclerosis. J Clin Neurol 2015; 11: 9-19.
- Ceronie B, Jacobs BM, Baker D, et al. Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells. J Neurol 2018; 265:1199-1209.
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