Migraine prophylaxis: evidenced options

Evidence-based neurology checklist on migraine prophylaxis: evidenced options: Betablockers: Propranolol The starting dose is 40mg daily It is increased by 40mg weekly The maintenance dose is 40-120mg bid Betablockers: others Topiramate Candesartan Frovatriptan Amitriptyline Valproate Flunarizine…

Betablockers: Propranolol

  • The starting dose is 40mg daily
  • It is increased by 40mg weekly
  • The maintenance dose is 40-120mg bid

Betablockers: others

Topiramate

Candesartan

Frovatriptan

Amitriptyline

Valproate

Flunarizine

CGRP monoclonal antibodies

Dual therapy

Acronym

References

  1. Eigenbrodt AK, Ashina H, Khan S, et al. Diagnosis and management of migraine in ten steps. Nat Rev Neurol 2021; 17:501-514.
  2. Silberstein SD, Holland S, Freitag F, et al. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology 2012; 78:1337-1345.
  3. MacGregor EA, Steiner TJ, Davies PTG. British Association for the Study of Headaches (BASH). Guidelines for all healthcare professionals in the diagnosis and management of migraine, tension-type, cluster and medication-overuse headache. September 2010.
  4. Sprenger T, Viana M, Tassorelli C. Current prophylactic medications for migraine and their potential mechanisms of action. Neurotherapeutics 2018; 15:313-323.
  5. Hovaguimian A, Roth J. Management of chronic migraine. BMJ 2022; 379:e067670. 
  6. And 9 more. Subscribe to see the full list

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