MELAS stroke-like episodes (SLEs): radiological features
Evidence-based neurology checklist on melas stroke-like episodes (sles): radiological features: Features of stroke like lesions There are focal or multifocal lesions These may be cortical or subcortical They may be symmetrical They are dynamic They progressively expand over days to months They do…
Features of stroke like lesions
- There are focal or multifocal lesions
- These may be cortical or subcortical
- They may be symmetrical
- They are dynamic
- They progressively expand over days to months
- They do not conform to vascular territories
- They appear as cytotoxic oedema and progress to vasogenic oedema
- They manifest as hyper-perfusion on perfusion studies
Radiological patterns
Radiological outcomes
Differential diagnosis
Distinguishing features from ischaemic stroke
Acronym
References
- Finsterer J, Aliyev R. Metabolic stroke or stroke-like lesion: peculiarities of a phenomenon. J Neurol Sci 2020; 412:116726.
- Finsterer J. Mitochondrial metabolic stroke: phenotype and genetics of stroke-like episodes. J Neurol Sci 2019; 400:135-141.
- Finsterer J. Therapeutic management of stroke-like episodes varies from that of encephalitis. Medicine (Baltimore) 2020; 99:e19141.
- Martinez-Fernandez E, Gil-Peralta A, Garcia-Lozano R, et al. Mitochondrial disease and stroke. Stroke 2001; 32:2507-2510.
- Durrleman C, Grevent D, Aubart M, et al. Clinical and radiological description of 120 pediatric stroke-like episodes. Eur J Neurol 2023; 30:2051-2061.
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