Marburg variant multiple sclerosis

Evidence-based neurology checklist on marburg variant multiple sclerosis: Pathology This is a fulminant pseudotumour form of multiple sclerosis (MS) It progresses over weeks to months It has a high morbidity and mortality Clinical features Differential diagnosis Magnetic resonance imaging (MRI)…

Pathology

  • This is a fulminant pseudotumour form of multiple sclerosis (MS)
  • It progresses over weeks to months
  • It has a high morbidity and mortality

Clinical features

Differential diagnosis

Magnetic resonance imaging (MRI)

Cerebrospinal fluid (CSF) analysis

Brain biopsy

Treatment

Usually ineffective treatments

Synonym

References

  1. Capet N, Levraut M, Delourme A, et al. Marburg multiple sclerosis variant: complete remission with very early administration of mitoxantrone-a case report. Neurol Ther 2021 (Online ahead of print).
  2. Elenein RG, Sharer LR, Cook SD, Pachner AR, Michaels J, Hillen ME. A second case of Marburg's variant of multiple sclerosis with vasculitis and extensive demyelination. Mult Scler 2011; 17:1531-1538.
  3. Manuel A, Vasudevan MC. A case of Marburg's variant of multiple sclerosis successfully treated with IVIg and mitoxantrone. Ann Indian Acad Neurol 2021; 24:92-94. 
  4. Turatti M, Gajofatto A, Rossi F, Vedovello M, Benedetti MD. Long survival and clinical stability in Marburg's variant multiple sclerosis. Neurol Sci 2010; 31:807-811. 
  5. AlOhaly N, Nathoo N, Schmitt LM, McCombe JA Dr. Lymphomatosis cerebri masquerading as the Marburg variant of multiple sclerosis. Mult Scler Relat Disord 2020; 46:102488.
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