MADSAM (Lewis Sumner syndrome)
Evidence-based neurology checklist on madsam (lewis sumner syndrome): Demographic features This is probably an asymmetrical variant of CIDP It has a male predominance The mean onset age is 40-50 years Clinical features Differential diagnosis: similarities with MMN Differential diagnosis:…
Demographic features
- This is probably an asymmetrical variant of CIDP
- It has a male predominance
- The mean onset age is 40-50 years
Clinical features
Differential diagnosis: similarities with MMN
Differential diagnosis: differences with MMN
Magnetic resonance imaging (MRI): features
Other investigations
Treatment
Acronym
References
- Viala K, Renie L, Maisonobe T, et al. Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome. Brain 2004; 127:2010-2017.
- Kuwahara M, Numoto I, Kusunoki S. Multifocal nodular hypertrophy of trigeminal nerve in multifocal acquired demyelinating sensory and motor neuropathy. Neurol Neuroimmunol Neuroinflamm 2019; 6:e553.
- Verschueren A, Azulay JP, Attarian S, Boucraut J, Pellissier JF, Pouget J. Lewis-Sumner syndrome and multifocal motor neuropathy. Muscle Nerve 2005; 31:88-94.
- Saperstein DS, Amato AA, Wolfe GI, et al. Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome. Muscle Nerve 1999; 22:560-566.
- Shimizu F, Oishi M, Sawai S, et al. Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy. JNNP 2019; 90:444-450.
