Locked in syndrome (LIS): pathology

Evidence-based neurology checklist on locked in syndrome (lis): pathology: Pathology This is usually caused by lesions in the ventral pons It may also result from extensive bilateral corticobulbar and corticospinal tract destruction It may be transient or chronic Classification Primary causes…

Pathology

  • This is usually caused by lesions in the ventral pons
  • It may also result from extensive bilateral corticobulbar and corticospinal tract destruction
  • It may be transient or chronic

Classification

Primary causes

Iatrogenic causes

References

  1. Smith E, Delargy M. Locked-in syndrome. BMJ 2005; 330:406-409.
  2. Schnetzer L, McCoy M, Bergmann J, Kunz A, Leis S, Trinka E. Locked-in syndrome revisited. Ther Adv Neurol Disord 2023; 16:17562864231160873.
  3. Halan T, Ortiz JF, Reddy D, Altamimi A, Ajibowo AO, Fabara SP. Locked-in syndrome: a systematic review of long-term management and prognosis. Cureus 2021; 13:e16727. 
  4. Senthilkumaran S, Balamurugan N, Karthikeyan N, Thirumalaikolundusubramanian P. Snakebite mimicking brain death: bedside clues. Indian J Crit Care Med 2021; 25:1464.

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