Lacosamide: clinical use
Evidence-based neurology checklist on lacosamide: clinical use: Mode of action Lacosamide enhances the slow inactivation of voltage-gated sodium channels Indications Dosing Precautions
Mode of action
- Lacosamide enhances the slow inactivation of voltage-gated sodium channels
Indications
Dosing
Precautions
References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Scott LJ. Lacosamide: a review in focal seizures in patients with epilepsy. Drugs 2015; 75:2143-2154.
- d'Orsi G, Pascarella MG, Martino T, et al. Intravenous lacosamide in seizure emergencies: Observations from a hospitalized in-patient adult population. Seizure 2016; 42:20-28.
- Legros B, Depondt C, Levy-Nogueira M, et al. Intravenous lacosamide in refractory seizure clusters and status epilepticus: comparison of 200 and 400 mg loading doses. Neurocrit Care 2014; 20:484-488.
- Moreno Morales EY, Fernandez Peleteiro M, Bondy Peña EC, Domínguez Lorenzo JM, Pardellas Santiago E, Fernández A. Observational study of intravenous lacosamide in patients with convulsive versus non-convulsive status epilepticus. Clin Drug Investig 2015; 35:463-469.
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