Lacosamide: adverse effects

Evidence-based neurology checklist on lacosamide: adverse effects: Neurological side effects Headache Dizziness Diplopia Vertigo Ataxia Tremor Tics Worsening of seizures HyperCKaemia Dyskinesias Psychiatric side effects Cardiac side effects Systemic side effects

Neurological side effects

  • Headache
  • Dizziness
  • Diplopia
  • Vertigo
  • Ataxia
  • Tremor
  • Tics
  • Worsening of seizures
  • HyperCKaemia
  • Dyskinesias

Psychiatric side effects

Cardiac side effects

Systemic side effects

References

  1. Hoy SM. Lacosamide: a review of its use as adjunctive therapy in the management of partial-onset seizures. CNS Drugs 2013; 27:1125-1142.
  2. Zaccara G, Perucca P, Loiacono G, Giovannelli F, Verrotti A. The adverse event profile of lacosamide: a systematic review and meta-analysis of randomized controlled trials. Epilepsia 2013; 54:66-74.
  3. Krauss G, Ben-Menachem E, Mameniskiene R, et al; SP757 Study Group. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures. Epilepsia 2010; 51:951-957. 
  4. Guilhoto LM, Loddenkemper T, Gooty VD, et al. Experience with lacosamide in a series of children with drug-resistant focal epilepsy. Pediatr Neurol 2011; 44:414-419. 
  5. Matsudaira T, Terada T, Araki Y, Ikeda H, Obi T, Inoue Y. HyperCKemia associated with lacosamide therapy in an elderly patient with focal onset epilepsy. Seizure 2018; 63:14-16. 
  6. And 10 more. Subscribe to see the full list

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