Human herpes virus 6 (HHV-6) infection: post-transplant limbic encephalitis (PALE)

Evidence-based neurology checklist on human herpes virus 6 (hhv-6) infection: post-transplant limbic encephalitis (pale): Pathology This follows hematopoietic stem cell transplantation (HSCT) The onset is 2-6 weeks after transplant It may be associated with delayed engraftment Risk factors…

Pathology

  • This follows hematopoietic stem cell transplantation (HSCT)
  • The onset is 2-6 weeks after transplant
  • It may be associated with delayed engraftment

Risk factors

Neurological features

Systemic features

Complications

Poor prognostic factors

Magnetic resonance imaging (MRI) brain

Other investigations

Treatment

Prevention

Acronym

References

  1. Berzero G, Campanini G, Vegezzi E, et al. Human herpesvirus 6 encephalitis in immunocompetent and immunocompromised hosts. Neurol Neuroimmunol Neuroinflamm 2021; 8:e942.
  2. Berger JR. Learning more about HHV-6 encephalitis. Neurol Neuroimmunol Neuroinflamm 2021 (online ahead of print).
  3. Bhanushali MJ, Kranick SM, Freeman AF, et al. Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation. Neurology 2013; 80:1494-1500.
  4. Ogata M, Fukuda T, Teshima T. Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know. Bone Marrow Transplant 2015; 50:1030-1036.
  5. Miyashita N, Endo T, Onozawa M, et al. Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 2017 (online ahead of print).
  6. And 15 more. Subscribe to see the full list

Related checklists

Loading...