Human herpes virus 6 (HHV-6) infection: clinical presentations

Encephalitis with other immunocompromised states

• Solid organ transplantation
• Conventional immunosuppressive treatments
• Chimeric antigen receptor (CAR) T-cell therapy
• Biological immunotherapies

Rhombencephalitis

Roseola infantum (exanthem subitum, sixth disease)

Other neurological manifestations

References

1. Berzero G, Campanini G, Vegezzi E, et al. Human herpesvirus 6 encephalitis in immunocompetent and immunocompromised hosts. Neurol Neuroimmunol Neuroinflamm 2021; 8:e942.
2. Berger JR. Learning more about HHV-6 encephalitis. Neurol Neuroimmunol Neuroinflamm 2021 (online ahead of print).
3. Lautenschlager I, Razonable RR. Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review. Transpl Int 2012; 25:493-502.
4. Vinnard C, Barton T, Jerud E, Blumberg E. A report of human herpesvirus 6-associated encephalitis in a solid organ transplant recipient and a review of previously published cases. Liver Transpl 2009; 15:1242-1246. 
5. Yamamoto T, Watarai Y, Goto N, et al. Encephalitis caused by human herpesvirus-6B in pancreas-after-kidney transplantation. Transpl Infect Dis 2014; 16:853-858. 
6. And 19 more. Subscribe to see the full list

Related checklists

• Human herpes virus 6 (HHV-6) infection: post-transplant limbic encephalitis (PALE)
• Human herpes virus 6 (HHV-6) infection: differential diagnosis
• Human herpes virus 6 (HHV-6) infection: management