Holmes-Adie syndrome (HAS)

Evidence-based neurology checklist on holmes-adie syndrome (has): Diagnostic triad Tonic pupils Near-light dissociation Areflexia Pathology Ophthalmic features Neurological features Autonomic features Differential diagnosis: secondary causes of tonic pupils Investigation: dilute pilocarpine test…

Diagnostic triad

  • Tonic pupils
  • Near-light dissociation
  • Areflexia

Pathology

Ophthalmic features

Neurological features

Autonomic features

Differential diagnosis: secondary causes of tonic pupils

Investigation: dilute pilocarpine test

Treatment

Synonym

References

  1. Kimber J, Mitchell D, Mathias CJ. Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction. JNNP 1998; 65:583-586.
  2. Xu SY, Song MM, Li L, Li CX. Adie's pupil: a diagnostic challenge for the physician. Med Sci Monit 2022; 28:e934657.
  3. Colak S, Erdogan MO, Senel A, et al. A rare case in the emergency department: Holmes-Adie Syndrome. Turk J Emerg Med 2016; 15:40-42.
  4. Bacon PJ, Smith SE. Cardiovascular and sweating dysfunction in patients with Holmes-Adie syndrome. JNNP 1993; 56:1096-1102.
  5. Mak W, Cheung RT. The Holmes-Adie plus syndrome. J Clin Neurosci 2000; 7:452.
  6. And 5 more. Subscribe to see the full list

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