Hereditary spastic paraplegia type 89 (SPG89)

Evidence-based neurology checklist on hereditary spastic paraplegia type 89 (spg89): Genetics This is caused by mutations in the AMFR gene The gene is on chromosome 16 The transmission is autosomal recessive Neurological features Magnetic resonance imaging (MRI) brain

Genetics

  • This is caused by mutations in the AMFR gene
  • The gene is on chromosome 16
  • The transmission is autosomal recessive

Neurological features

Magnetic resonance imaging (MRI) brain

References

  1. Deng R, Medico-Salsench E, Nikoncuk A, et al. AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Acta Neuropathol 2023; 146:353-368.

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