Hereditary spastic paraplegia type 77 (SPG77)

Evidence-based neurology checklist on hereditary spastic paraplegia type 77 (spg77): Genetics This is caused by mutations in the FARS2 gene on chromosome 6p The transmission is autosomal recessive It is childhood onset Clinical features Magnetic resonance imaging (MRI) brain

Genetics

  • This is caused by mutations in the FARS2 gene on chromosome 6p
  • The transmission is autosomal recessive
  • It is childhood onset

Clinical features

Magnetic resonance imaging (MRI) brain

References

  1. Yang Y, Liu W, Fang Z, Shi J, Che F, He C, Yao L, Wang E, Wu Y. A newly identified missense mutation in FARS2 causes autosomal-recessive spastic paraplegia. Hum Mutat 2016; 37:165-169.
  2. Forman EB, Gorman KM, Ennis S, King MD.FARS2 causing complex hereditary spastic paraplegia with dysphonia: expanding the disease spectrum. J Child Neurol 2019; 34:621.

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